VizBrCells_English

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ABOUT

TEAM

CONTACT

PROJECT

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Develop a tool for

Vizualizing Brain Cells

SINCE.2020

ABOUT VizBrCells

To understand brain systems

and to handle brain disorders,

we try to make tools

for visualizing a type of brain cells

OUR Scheme

1. Screening cadndiates in fluorescent molecule libraries based on the diversity of brain cell types

2. Evaluate the type of brain cells using molecular and cellular biochemical methods

3. Neurobiological studies by applying the molecule for imaging/tracking the live brain cells

4. Mechanism study to identify the target biomolecule of the fluorescent molecule

ABOUT VizBrCells

To understand brain systems and to handle brain disorders,

we try to make tools for visualizing a type of brain cells

SCHEME

1. Screening cadndiates in fluorescent molecule libraries based on the diversity of brain cell types

2. Evaluate the type of brain cells using molecular and cellular biochemical methods

3. Neurobiological studies by applying the molecule for imaging/tracking the live brain cells

4. Mechanism study to identify the target biomolecule of the fluorescent molecule

COLLABORATION

Through active co-work with chemists, novel fluorescent probes have synthesized

CREDENTIAL

By applying a creative screening platform, we give own ID to an unsung chemical

CONTRIBUTION

After identifying its brain target, we can provide an innovative tool for tracking a type of brain cells

Primary glial culture

Microglia (CDr20)

Nuclei (Hoechst33342)

Primary glial culture

1. Normal condition

2, 3. ADP treat

1. Phase contrast

2. CDr20 fluorescence

OUR TEAM

We are the bridge of science.

(Click image for more details)

KIM, Beomsue (PI)

Click for more

Lab Head: Beomsue Kim, Ph.D.

20-Current, Senior Researcher, Neural Circuit Group, Korea Brain Research Insisisute (KBRI)

14-19, Research Fellow, Singapore Bioimaging Consortium, A-STAR, Singapore

13-14, Research Fellow, Dpt. Chemistry, NUS, Singapore

09-13, Research Fellow, Dpt. Pharmacology, Ajou University

05-09, Ph.D., Neural Science & Technology, Ajou University, Korea

03-04, Visiting Scholar, Dpt. Pediatrics, UTHSC, TN, USA

01-03, M.Sc, Life Science, Hanyang University, Korea

97-01, B.Sc., Biology, Hanyang University, Korea

Wonju Kim (Ph.D.)

Postdoctoral Research Fellow (2023.05 - )

Dong-Wan Go

Research Fellow (2021.08 - )

Min-Ji Kim (M.Sc)

Research Fellow (2023.05 - )

Aleksander Szawan

Intern Student (Cardiff University, 2024.10 - )

Positions have opened (Research fellow for MSc/PhD holders, etc.)

If interest, please send e-mail with your CV to kimbs@kbri.re.kr.

CONTACT

PROJECT

SINCE.2020~

Development of a tool for :

1. tracking subcellular organelle of microglia using click chemistry

2. tracking a human brain cell using iPSC-derived brain organoid

3. tracking oligodendrocytes in specific stages of development

4. imaging choof roid plexus of the brain in various species

5. making a small-size organoid to use imaging-based studies

The study of :

1. Identify CDr20 as a novel immunotypic molecule based on its activity to mUGT1A7C

2. Target Identification of CDr20 in human

3. Target Identification of NeuO

PUBLICATIONS

Unraveling the enigma: housekeeping gene Ugt1a7c as a universal biomarker for microglia. Front. Psychiatry. 2024; 15: 1364201. W Kim, M Kim, B Kim*. (Perspective)

Distinctive Labeling of Live Monocytes and Neutrophils with a Single Fluorescent Molecule. Chemosensors. 2023; 11(5): 265. S Kim, M Fukuda, JY Lee, YT Chang, HS Je, B Kim*.

LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition. Anim. Cells Syst. 2022; 26(6): 380–387. B. Kim*, YH Suh, E Joe*. (*, co-corresponding authors)

A brief review of non-invasive brain imaging technologies and the near-infrared optical bioimaging. Appl Microsc. 2021 Jun 25;51(1):9. B Kim*, H Kim, S Kim, YR Hwang. (*, corresponding author)

A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2. J Am Chem Soc. 2019 Sep 18;141(37):14673-14686. JJ Kim, YA Lee, D Su, J Lee, SJ Park, B Kim, Jane, JH Lee, X Liu, SS Kim, MA Bae, JS Lee, SC Hong, L Wang, A Samanta, HY Kwon, SY Choi, JY Kim, YH Yu, HH Ha, Z Wang, WL Tam, B Lim, NY Kang, YT Chang.

Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate. Angew Chem Int Ed Engl. 2019 Jun 11;58(24):7972-7976. B Kim #, M Fukuda #, JY Lee, D Su, S Sanu, A Silvin, ATT Khoo, T Kwon, X Liu , W Chi, X Liu, S Choi, DSY Wan, SJ Park, JS Kim, F Ginhoux, HS Je, YT Chang. (Frontispiece, VIP, #; co-first authors)

Development of a Universal Fluorescent Probe for Gram-Positive Bacteria. Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8426-8431. HY Kwon, X Liu, EG Choi, JY Lee, SY Choi, JY Kim, L Wang, SJ Park, B Kim, YA Lee, JJ Kim, NY Kang, YT Chang.

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Nat Commun. 2019 Mar 7;10(1):1111. SJ Park#, B Kim#, S Choi#, S Balasubramaniam, SC Lee, JY Lee, HS Kim, JY Kim, JJ Kim, YA Lee, NY Kang, JS Kim, YT Chang. (#; co-first authors)

A Fluorescent Probe for Neural Stem/Progenitor Cells with High Differentiation Capability into Neurons. Chembiochem. 2016 Nov 17;17(22):2118-2122. B Kim, S Feng, SW Yun, C Leong, R Satapathy, SY Wan, YT Chang. (Front Cover)

ADRESS

61, Cheomdan-ro, Dong-gu, Daegu, 41062. Korea

PHONE NUMBER

053-980-8412

E-MAIL

kimbs@kbri.re.kr

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